CETUXIMAB IN COMBINATION WITH IRINOTECAN/5-FLUOROURACIL/FOLINIC ACID (FOLFIRI) IN THE INITIAL TREATMENT OF METASTATIC COLORECTAL CANCER: A MULTICENTRE TWO-PART PHASE I/II STUDY

Abstract Background This study was designed to investigate the efficacy and safety of the epidermal growth factor receptor (EGFR) inhibitor cetuximab combined with irinotecan, folinic acid (FA) and two different doses of infusional 5-fluorouracil (5-FU) in the first-line Abrasive treatment of EGFR-detectable metastatic colorectal cancer.Methods The

In a study to compare the effectiveness of some essential oil nanoemulsion and bioproducts as an alternative to chemical nematicide in control of root-knot nematode, Meloidogyne incognita parasitizing on chili pepper, Capsicum annuum L.plants, in parallel with the plant growth and yield under two varying conditions; in vitro, greenhouse and plastic

Quality of malting barley of given harvest is proved in RIBM, Plc., Malting Institute Brno, every year for a long time.There is comparison of results from 2000 and 2004 harvests, which were - every from different point of view - problematic, presented in the article.From the aspect of the harvested amount, average yield and barley technological qua

Energy management in industrial plants requires measurements of the steam flow rates at each usage location.A clamp-on ultrasonic flowmeter can be used to effectively measure the steam flow rates in existing pipes.An ultrasonic flowmeter is used to calculate the transit time of ultrasonic signals between the downstream and upstream sensors, which i

Introduction: Surgical site infections (SSIs) pose a global health concern.While various pathogenic microorganisms can cause SSIs, a predominant causative agent is Staphylococcus aureus, particularly its methicillin-resistant strain (MRSA).MRSA, known for its resistance to multiple antibiotics, significantly complicates treatment options, leading t